Duration of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
نویسندگان
چکیده
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.
منابع مشابه
Pharmacologic limits of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.
Polyaspartic acid (PAA) ameliorates experimental gentamicin nephrotoxicity despite marked accumulation of gentamicin in the renal cortex. The experiments described here probe the extent of PAA's nephroprotective action when increasing doses of gentamicin, in excess of an established nephrotoxic dose (40 mg/kg of body weight per day), are administered. After 10 days, virtually complete nephropro...
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Background and Methodology: Gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as Nephrotoxicity and autotoxicity. Cinnamon bark has antioxidant properties. This is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.Methods and Materials: Thirty-six mature femal...
متن کاملProtective Effects of Cinnamon Bark Hydroalcoholic Extract on Gentamicin-induced Nephrotoxicity in Mature Rats
Background and Methodology: Gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as Nephrotoxicity and autotoxicity. Cinnamon bark has antioxidant properties. This is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.Methods and Materials: Thirty-six mature femal...
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ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 36 11 شماره
صفحات -
تاریخ انتشار 1992